PTPN12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa (Lane 1), MCF-7 (Lane 2), HepG2 (Lane 3) and HEK293 (Lane 4) lysate with PTPN12 polyclonal antibody (Cat # PAB18893) at 1 : 500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human colon carcinoma tissue showing cytoplasmic staining with PTPN12 polyclonal antibody (Cat # PAB18893) at 1 : 100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant PTPN12.
Immunogen
Recombinant protein corresponding to amino acids 544-771 of human PTPN12.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:10000-1:80000)
Western Blot (1:200-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa (Lane 1), MCF-7 (Lane 2), HepG2 (Lane 3) and HEK293 (Lane 4) lysate with PTPN12 polyclonal antibody (Cat # PAB18893) at 1 : 500 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human colon carcinoma tissue showing cytoplasmic staining with PTPN12 polyclonal antibody (Cat # PAB18893) at 1 : 100 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTPN12
Entrez GeneID
5782Protein Accession#
NM_002835Gene Name
PTPN12
Gene Alias
PTP-PEST, PTPG1
Gene Description
protein tyrosine phosphatase, non-receptor type 12
Omim ID
600079Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000025119|protein-tyrosine phosphatase G1|tyrosine-protein phosphatase non-receptor type 12
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Interactome
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Disease
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