Western blot analysis of ADAM17 polyclonal antibody (Cat # PAB1888) in CEM cell line lysates (35 ug/lane). ADAM17 (arrow) was detected using the purified polyclonal antibody.
Flow cytometric analysis of CEM cells using ADAM17 polyclonal antibody (Cat # PAB1888)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq