PAK4 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HeLa (Lane 1) and MCF-7 (Lane 2) cell lysate with PAK4 polyclonal antibody (Cat # PAB18878) at 1 : 250 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PAK4.
Immunogen
A synthetic peptide corresponding to 14 amino acids at N-terminus of human PAK4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
ELISA (1:10000-1:40000)
Western Blot (1:200-1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa (Lane 1) and MCF-7 (Lane 2) cell lysate with PAK4 polyclonal antibody (Cat # PAB18878) at 1 : 250 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PAK4
Entrez GeneID
10298Protein Accession#
AB032968Gene Name
PAK4
Gene Alias
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Gene Description
p21 protein (Cdc42/Rac)-activated kinase 4
Omim ID
605451Gene Ontology
HyperlinkGene Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq
Other Designations
p21(CDKN1A)-activated kinase 4|p21-activated kinase 4|protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
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Interactome
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Pathway
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Disease
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