CNTFR polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain tissue showing membrane staining with CNTFR polyclonal antibody (Cat # PAB18803) at 1 : 100 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CNTFR.
Immunogen
A synthetic peptide corresponding to 14 amino acids at internal region of human CNTFR.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Peptide affinity purification
Recommend Usage
ELISA (1:8000-1:30000)
Western Blot (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed paraffin-embedded human brain tissue showing membrane staining with CNTFR polyclonal antibody (Cat # PAB18803) at 1 : 100 dilution.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CNTFR
Entrez GeneID
1271Gene Name
CNTFR
Gene Alias
MGC1774
Gene Description
ciliary neurotrophic factor receptor
Omim ID
118946Gene Ontology
HyperlinkGene Summary
This gene encodes a hematopoeitin/interferon-class receptor belonging to the cytokine superfamily of receptors. The encoded gene product represents the CNTF-specific alpha subunit of a heterotrimer forming the CNTF receptor complex, which also includes LIFR and gp130. The receptor is attached to the membrane by a glycosyl-phosphatidylinositol linkage and contains an immunoglobulin-like C2-type domain and a fibronectin type-III domain. Signal transduction requires that CNTF bind first to this alpha component, which permits the recruitment of gp130 and LIFR beta to form the tripartite receptor complex. Signal transduction stimulates gene expression, cell survival or differentiation in a variety of neuronal cell types. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq
Other Designations
CNTFR alpha|OTTHUMP00000021270|OTTHUMP00000021271|ciliary neurotrophic factor receptor alpha
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Interactome
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