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Last updated: 2016/12/4
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DEFA1/DEFA3 polyclonal antibody

  • Catalog # : PAB18743
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of DEFA1/DEFA3.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human DEFA1/DEFA3.
  • Sequence:
  • C-DESLAPKHPGSRKN
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 10.2
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to equally recognize DEFA1 precursor and DEFA3 precursor.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:128000)
    Western Blot (1-3 ug/mL)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-6 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • DEFA1|DEFA3 polyclonal antibody (Cat # PAB18743) (2 ug/mL) staining of human spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • DEFA1|DEFA3 polyclonal antibody (Cat # PAB18743) (3.8 ug/mL) staining of paraffin embedded human thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 1667
  • Protein Accession#:
  • NP_004075.1 (Gene ID : 1667);NP_005208.1 (Gene ID : 1668)
  • Gene Name:
  • DEFA1
  • Gene Alias:
  • DEF1,DEFA2,HNP-1,HP-1,MGC138393,MRS
  • Gene Description:
  • defensin, alpha 1
  • Gene Summary:
  • Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 3 by only one amino acid. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000196017,defensin, alpha 1, myeloid-related sequence,defensin, alpha 2,myeloid-related sequence
  • Gene Information
  • Entrez GeneID:
  • 1668
  • Protein Accession#:
  • NP_004075.1 (Gene ID : 1667);NP_005208.1 (Gene ID : 1668)
  • Gene Name:
  • DEFA3
  • Gene Alias:
  • DEF3,HNP-3,HNP3,HP-3
  • Gene Description:
  • defensin, alpha 3, neutrophil-specific
  • Gene Summary:
  • Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 1 by only one amino acid. [provided by RefSeq
  • Other Designations:
  • defensin 3, neutrophil-specific,defensin, alpha 3,neutrophil peptide 3
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