LASS1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
LASS1 polyclonal antibody (Cat # PAB18693) (1 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LASS1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human LASS1.
Sequence
C-KDLREYDTAEAQ
Host
Goat
Theoretical MW (kDa)
37
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_067090.1and NP_937850.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
LASS1 polyclonal antibody (Cat # PAB18693) (1 ug/mL) staining of human frontal cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LASS1
Entrez GeneID
10715Protein Accession#
NP_067090.1;NP_937850.1Gene Name
LASS1
Gene Alias
CerS1, LAG1, MGC90349, UOG1
Gene Description
LAG1 homolog, ceramide synthase 1
Omim ID
606919Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq
Other Designations
LAG1 longevity assurance homolog 1|longevity assurance (LAG1, S. cerevisiae) homolog 1|longevity assurance gene 1|upstream of GDF1
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Interactome
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Publication Reference
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Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.
Chisato Inoue, Sayaka Sobue, Naoki Mizutani, Yoshiyuki Kawamoto, Yuji Nishizawa, Masatoshi Ichihara, Toshiyuki Takeuchi, Fumihiko Hayakawa, Motoshi Suzuki, Tetsuro Ito, Yoshinori Nozawa, Takashi Murate.
Nagoya Journal of Medical Science 2020 May; 82(2):261.
Application：WB-Ce, WB-Tr, Human, K-562 cells.
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Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes.
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