TH polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TH.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human TH.
Sequence
C-VQDELDTLAHAL
Host
Goat
Theoretical MW (kDa)
55
Reactivity
Human
Specificity
This antibody is expected to recognise all three reported isoforms (as represented by NP_954986.2; NP_000351.2; NP_954987.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
TH polyclonal antibody (Cat # PAB18662) (2 ug/mL) staining of human cerebral cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TH
Entrez GeneID
7054Protein Accession#
NP_954986.2;NP_000351.2;NP_954987.2Gene Name
TH
Gene Alias
TYH
Gene Description
tyrosine hydroxylase
Omim ID
191290Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000011225|OTTHUMP00000011226|tyrosine 3-monooxygenase
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Interactome
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Pathway
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Disease
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