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Last updated: 2017/3/19
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NIPBL polyclonal antibody

  • Catalog # : PAB18614
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of NIPBL.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 889-902 at internal region of human NIPBL.
  • Sequence:
  • C-RPDSPRVKQGDSNK
  • Host:
  • Goat
  • Specificity:
  • This antibody is expected to recognize both reported isoforms (NP_597677.2; NP_056199.2).
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:32000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Protein Accession#:
  • NP_597677.2;NP_056199.2
  • Gene Name:
  • NIPBL
  • Gene Alias:
  • CDLS,CDLS1,DKFZp434L1319,FLJ11203,FLJ12597,FLJ13354,FLJ13648,FLJ44854,IDN3,IDN3-B
  • Gene Description:
  • Nipped-B homolog (Drosophila)
  • Gene Summary:
  • This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000116005,SCC2 homolog,delangin,nipped-B-like
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