NIPBL polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of NIPBL.
Immunogen
A synthetic peptide corresponding to amino acids 889-902 at internal region of human NIPBL.
Sequence
C-RPDSPRVKQGDSNK
Host
Goat
Specificity
This antibody is expected to recognize both reported isoforms (NP_597677.2; NP_056199.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — NIPBL
Entrez GeneID
25836Protein Accession#
NP_597677.2;NP_056199.2Gene Name
NIPBL
Gene Alias
CDLS, CDLS1, DKFZp434L1319, FLJ11203, FLJ12597, FLJ13354, FLJ13648, FLJ44854, IDN3, IDN3-B
Gene Description
Nipped-B homolog (Drosophila)
Gene Ontology
HyperlinkGene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and mental retardation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000116005|SCC2 homolog|delangin|nipped-B-like
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Interactome
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Disease
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