BCL2L11 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL2L11.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to BH3 domain of human BCL2L11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
The BCL2L11 polyclonal antibody (Cat # PAB1861) is used in Western blot to detect BCL2L11 in HL-60 cell lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with BCL2L11 polyclonal antibody (Cat # PAB1861), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — BCL2L11
Entrez GeneID
10018Protein Accession#
NP_619527;O43521Gene Name
BCL2L11
Gene Alias
BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL
Gene Description
BCL2-like 11 (apoptosis facilitator)
Omim ID
603827Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq
Other Designations
BCL2-like 11|bcl-2 interacting mediator of cell death|bcl-2 interacting protein Bim|bcl-2-related ovarian death agonist
-
Interactomes
-
Diseases
-
Publication Reference
-
Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling.
Chen D, Zhou Q.
PNAS 2004 Jan; 101(5):1235.
Application:WB, Human, Mouse, HEK 293T cells, Jurkat cells, Mouse primary T cells.
-
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
Sunters A, Fernandez de Mattos S, Stahl M, Brosens JJ, Zoumpoulidou G, Saunders CA, Coffer PJ, Medema RH, Coombes RC, Lam EW.
The Journal of Biological Chemistry 2003 Dec; 278(50):49795.
Application:WB, Human, 734B, CAL-51, CAMA-1, HMT3552, MCF-7, MDA-MB-231, SKBR-7, T47-D, ZR-75-1 cells.
-
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P.
Oncogene 2003 Oct; 22(43):6785.
Application:WB, Human, HEK 293 cells.
-
Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com