PLA2G4A polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PLA2G4A.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human PLA2G4A.
Sequence
C-QEKTFRQQRKEHIR
Host
Goat
Theoretical MW (kDa)
90
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
PLA2G4A polyclonal antibody (Cat # PAB18577) (1 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLA2G4A
Entrez GeneID
5321Protein Accession#
NP_077734.1Gene Name
PLA2G4A
Gene Alias
MGC126350, PLA2G4, cPLA2-alpha
Gene Description
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Omim ID
600522Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq
Other Designations
OTTHUMP00000033543|calcium-dependent phospholipid-binding protein|cytosolic phospholipase A2, group IVA|lysophospholipase|phosphatidylcholine 2-acylhydrolase
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Interactome
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Pathway
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Disease
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