LSP1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of LSP1.
Immunogen
A synthetic peptide corresponding to amino acids at C-terminus of human LSP1.
Sequence
C-RYKFVATGHGKYEKV
Host
Goat
Theoretical MW (kDa)
50
Reactivity
Human
Specificity
This antibody is expected to recognize both reported isoforms (NP_002330.1; NP_001013271.1). Reported variants represent identical protein: NP_001013273.1, NP_001013271.1, NP_001013272.1.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:16000)
Western Blot (0.05-0.2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
LSP1 polyclonal antibody (Cat # PAB18566) (0.05 ug/mL) staining of human liver lysate (lane 1), mouse liver lysate (lane 2) and rat liver lysate (lane 3) (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Western Blot (Cell lysate)
LSP1 polyclonal antibody (Cat # PAB18566) (0.05 ug/mL) staining of human peripheral lymphocytes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — LSP1
Entrez GeneID
4046Protein Accession#
NP_002330.1;NP_001013271.1Gene Name
LSP1
Gene Alias
WP34, pp52
Gene Description
lymphocyte-specific protein 1
Omim ID
153432Gene Ontology
HyperlinkGene Summary
This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
47 kDa actin binding protein|52 kDa phosphoprotein|F-actin binding and cytoskeleton associated protein|OTTHUMP00000014139|OTTHUMP00000069612|leufactin (leukocyte F-actin binding protein)|leukocyte-specific protein 1|lymphocyte-specific antigen WP34|lympho
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Interactome
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Disease
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Publication Reference
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Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.
Cervero P, Wiesner C, Bouissou A, Poincloux R, Linder S.
Nature Communications 2018 Feb; 9(1):515.
Application:IF, PLA-Ce, WB-Ce, WB-Tr, Human, Human macrophages.
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Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.
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