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Last updated: 2016/12/4
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GNAS polyclonal antibody

  • Catalog # : PAB18557
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of GNAS.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids at internal region of human GNAS.
  • Sequence:
  • C-QAARSNSDGEKATK
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 45
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is expected to recognize all three reported isoforms NP_000507.1, NP_001070956.1 and NP_536350.2.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:16000)
    Western Blot (1-3 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • GNAS polyclonal antibody (Cat # PAB18557) (1 ug/mL) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 2778
  • Protein Accession#:
  • NP_000507.1;NP_001070956.1;NP_001070957.1
  • Gene Name:
  • GNAS
  • Gene Alias:
  • AHO,C20orf45,GNAS1,GPSA,GSA,GSP,MGC33735,NESP,PHP1A,PHP1B,POH,dJ309F20.1.1,dJ806M20.3.3
  • Gene Description:
  • GNAS complex locus
  • Gene Summary:
  • This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000031740,OTTHUMP00000031756,OTTHUMP00000196026,OTTHUMP00000196030,adenylate cyclase-stimulating G alpha protein,guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1,guanine nucleotide regulatory protein,neuroe
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