DAG1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
DAG1 polyclonal antibody (Cat # PAB18550) (0.2 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of DAG1.
Immunogen
A synthetic peptide corresponding to amino acids at internal region of human DAG1.
Sequence
C-HVGKHEYFMHATDK
Host
Goat
Theoretical MW (kDa)
100
Reactivity
Human
Specificity
Reported variants represent identical protein: NP_001159400.1, NP_004384.3.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Western Blot (0.2-0.6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 0.5 mg/mL Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
DAG1 polyclonal antibody (Cat # PAB18550) (0.2 ug/mL) staining of human skeletal muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — DAG1
Entrez GeneID
1605Protein Accession#
NP_004384.3Gene Name
DAG1
Gene Alias
156DAG, A3a, AGRNR, DAG
Gene Description
dystroglycan 1 (dystrophin-associated glycoprotein 1)
Omim ID
128239Gene Ontology
HyperlinkGene Summary
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants
Other Designations
alpha-dystroglycan|beta-dystroglycan|dystroglycan 1|dystrophin-associated glycoprotein-1
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Interactome
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Pathway
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Disease
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