PIAS2 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PIAS2 polyclonal antibody (Cat # PAB1855), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PIAS2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PIAS2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with PIAS2 polyclonal antibody (Cat # PAB1855), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — PIAS2
Entrez GeneID
9063Protein Accession#
NP_775298;NP_004662;O75928-2;O75928-1Gene Name
PIAS2
Gene Alias
MGC102682, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz
Gene Description
protein inhibitor of activated STAT, 2
Omim ID
603567Gene Ontology
HyperlinkGene Summary
This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq
Other Designations
Msx-interacting-zinc finger|protein inhibitor of activated STAT X|zinc finger, MIZ-type containing 4
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Interactome
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Pathway
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Publication Reference
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A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.
Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J.
The Journal of Biological Chemistry 2004 Apr; 279(15):15505.
Application：WB-Tr, Human, HeLa cells.
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PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K.
The Journal of Biological Chemistry 2003 Apr; 278(24):21327.
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Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.
Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG.
Oncogene 2003 Jan; 22(3):351.
Application：IP-WB, WB-Ce, WB-Tr, Monkey, HL-60, Cos7 cells.
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A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.
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