SMC1A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SMC1A.
Immunogen
A synthetic peptide corresponding to residues surrounding S957 of human SMC1A.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to SMC1A.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells, treated with UV (15 mins), using SMC1A polyclonal antibody (Cat # PAB18499).
Peptide "+" means "peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — SMC1A
Entrez GeneID
8243Protein Accession#
Q14683Gene Name
SMC1A
Gene Alias
CDLS2, DKFZp686L19178, DXS423E, KIAA0178, MGC138332, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Gene Description
structural maintenance of chromosomes 1A
Gene Ontology
HyperlinkGene Summary
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq
Other Designations
OTTHUMP00000061876|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|SMC1 structural maintenance of chromosomes 1-like 1|segregation of mitotic chromosomes 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors.
Gan L, Zheng W, Chabot JG, Unterman TG, Quirion R.
Journal of Neurochemistry 2005 Jun; 93(5):1209.
Application:WB, Rat, PC-12 cells.
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Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna LA, Ruzzene M.
Cell Death and Differentiation 2005 Jun; 12(6):668.
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Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling and leads to an increased transit time through the G1 phase of the cell cycle.
Horn S, Endl E, Fehse B, Weck MM, Mayr GW, Jucker M.
Leukemia 2004 Nov; 18(11):1839.
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Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
Daisuke Nakajima, Noriko Okazaki, Hisashi Yamakawa, Reiko Kikuno, Osamu Ohara, Takahiro Nagase.
DNA Research 2002 Jun; 9(3):99.
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Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors.
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