Western blot analysis of extracts from LoVo cells (Lane 1) and Jurkat cells (Lane 2 and 3) treated with PMA (125 ng/mL, 30 min), using MARCKS polyclonal antibody (Cat # PAB18487). Peptide "+" means "peptide blocking".
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq
OTTHUMP00000017045,myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L),phosphomyristin