IRS1 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRS1.
Immunogen
A synthetic peptide corresponding to residues surrounding S639 of human IRS1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to IRS1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IRS1 polyclonal antibody (Cat # PAB18482).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRS1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD.
The Journal of Biological Chemistry 2004 Sep; 279(44):45304.
Application:IP-WB, Mouse, 3T3-L1, C2C12 cells.
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Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M.
Journal of Biological Chemistry 2003 May; 278(20):18440.
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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J.
The Journal of Biological Chemistry 2002 Dec; 277(50):48115.
Application:IP-WB, WB-Ce, WB-Tr, Human, HepG2, HEK 293 cells.
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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
PNAS 2001 Apr; 98(8):4640.
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Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
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