IRS1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRS1.
Immunogen
A synthetic peptide corresponding to residues surrounding S636/S639 of human IRS1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to IRS1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using IRS1 polyclonal antibody (Cat # PAB18481).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRS1
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Interactome
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Pathway
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Disease
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Publication Reference
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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Tzatsos A, Kandror KV.
Molecular and Cellular Biology 2006 Jan; 26(1):63.
Application:WB, Human, Mouse, Rat, 3T3-L1, C2C12 fibroblasts, HEK 293 cells, L6 myotubes.
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A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB.
PNAS 2001 Apr; 98(8):4640.
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Insights into insulin resistance and type 2 diabetes from knockout mouse models.
Kadowaki T.
The Journal of Clinical Investigation 2000 Aug; 106(4):459.
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Selective interaction between leptin and insulin signaling pathways in a hepatic cell line.
Szanto I, Kahn CR.
PNAS 2000 Feb; 97(5):2355.
Application:IP, WB-Ce, Rat, Fao cells.
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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
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