GRIA1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRIA1.
Immunogen
A synthetic peptide corresponding to residues surrounding S863 of human GRIA1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to GRIA1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COS-7 cells, using GRIA1 polyclonal antibody (Cat # PAB18474).
Peptide "+" means "peptide blocking".Immunohistochemistry
Immunofluorescence
Immunofluorescence analysis of A-549 cells, using GRIA1 polyclonal antibody (Cat # PAB18474).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRIA1
Entrez GeneID
2890Protein Accession#
P42261Gene Name
GRIA1
Gene Alias
GLUH1, GLUR1, GLURA, HBGR1, MGC133252
Gene Description
glutamate receptor, ionotropic, AMPA 1
Omim ID
138248Gene Ontology
HyperlinkGene Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AMPA 1
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Interactome
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Pathway
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Disease
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Publication Reference
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ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z.
Molecular Cell 2005 May; 18(5):577.
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD.
Nature 2005 Apr; 434(7035):907.
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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Falck J, Coates J, Jackson SP.
Nature 2005 Mar; 434(7033):605.
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ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
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