ESR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ESR1.
Immunogen
A synthetic peptide corresponding to residues surrounding S104/S106 of human ESR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ESR1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from MCF-7 cells, untreated or treated with Estradio, using ESR1 polyclonal antibody (Cat # PAB18472).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ESR1 polyclonal antibody (Cat # PAB18472).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ESR1
Entrez GeneID
2099Protein Accession#
P03372Gene Name
ESR1
Gene Alias
DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
Gene Description
estrogen receptor 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq
Other Designations
OTTHUMP00000017718|OTTHUMP00000017719|estrogen receptor alpha
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Interactome
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Disease
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Publication Reference
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p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
Liu Y, Wu C, Galaktionov K.
The Journal of Biological Chemistry 2003 Nov; 279(6):4507.
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Inhibition of cdk2 activating phosphorylation by mevastatin.
Ukomadu C, Dutta A.
The Journal of Biological Chemistry 2003 Feb; 278(7):4840.
Application:IP, WB-Tr, Human, PC-3 cells.
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Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.
Morris MC, Gondeau C, Tainer JA, Divita G.
The Journal of Biological Chemistry 2002 Jun; 277(26):23847.
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p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells.
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