DAB1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells (Lane 1 and 3) and 293 cells (Lane 2), using DAB1 polyclonal antibody (Cat # PAB18465).
Peptide "+" means "peptide blocking".
Immunofluorescence
Immunofluorescence analysis of MCF-7 cells, using DAB1 polyclonal antibody (Cat # PAB18465).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DAB1.
Immunogen
A synthetic peptide corresponding to residues surrounding Y232 of human DAB1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to DAB1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells (Lane 1 and 3) and 293 cells (Lane 2), using DAB1 polyclonal antibody (Cat # PAB18465).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of MCF-7 cells, using DAB1 polyclonal antibody (Cat # PAB18465).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — DAB1
Entrez GeneID
1600Protein Accession#
O75553Gene Name
DAB1
Gene Alias
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Gene Description
disabled homolog 1 (Drosophila)
Omim ID
603448Gene Ontology
HyperlinkGene Summary
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000010045|OTTHUMP00000011753|disabled homolog 1
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Interactome
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Disease
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Publication Reference
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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A.
Molecular and Cellular Biology 2004 May; 24(10):4184.
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Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex.
Xing Y, Clements WK, Kimelman D, Xu W.
Genes & Development 2003 Nov; 17(22):2753.
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A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.
Marin O, Bustos VH, Cesaro L, Meggio F, Pagano MA, Antonelli M, Allende CC, Pinna LA, Allende JE.
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep; 100(18):10193.
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A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.
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