PPP1R14A polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PPP1R14A.
Immunogen
A synthetic peptide corresponding to residues surrounding T38 of human PPP1R14A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to PPP1R14A.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HT-29 cells, using PPP1R14A polyclonal antibody (Cat # PAB18461).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human heart tissue using PPP1R14A polyclonal antibody (Cat # PAB18461).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using PPP1R14A polyclonal antibody (Cat # PAB18461).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — PPP1R14A
Entrez GeneID
94274Protein Accession#
Q96A00Gene Name
PPP1R14A
Gene Alias
CPI-17, CPI17, PPP1INL
Gene Description
protein phosphatase 1, regulatory (inhibitor) subunit 14A
Omim ID
608153Gene Ontology
HyperlinkGene Summary
PPP1R14A is a phosphorylation-dependent inhibitor of smooth muscle myosin phosphatase (see MIM 603768). Inhibition leads to increased myosin phosphorylation and enhances smooth muscle contraction in the absence of increased intracellular Ca(2+) concentration.[supplied by OMIM
Other Designations
17-KDa protein|17-kDa PKC-potentiated inhibitory protein of PP1|PKC-potentiated inhibitory protein of PP1
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Interactome
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Pathway
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Publication Reference
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PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
Moon EY, Lerner A.
Blood 2003 May; 101(10):4122.
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PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A.
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