CAMK2A/CAMK2D polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells (Lane 1) and NIH/3T3 cells (Lane 2 and 3), using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".
Immunofluorescence
Immunofluorescence analysis of MCF-7 cells, using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CAMK2A/CAMK2D.
Immunogen
A synthetic peptide corresponding to residues surrounding T286 of human CAMK2A/CAMK2D.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CAMK2A/CAMK2D.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells (Lane 1) and NIH/3T3 cells (Lane 2 and 3), using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of MCF-7 cells, using CAMK2A/CAMK2D polyclonal antibody (Cat # PAB18457).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CAMK2A
Entrez GeneID
815Protein Accession#
Q9UQM7Gene Name
CAMK2A
Gene Alias
CAMKA, KIAA0968
Gene Description
calcium/calmodulin-dependent protein kinase II alpha
Omim ID
114078Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
CaM kinase II alpha subunit|CaM-kinase II alpha chain|CaMK-II alpha subunit|CaMKIINalpha|OTTHUMP00000165787|OTTHUMP00000165788|calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha|calcium/calmodulin-dependent protein kinase II alpha-B subunit
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Gene Info — CAMK2D
Entrez GeneID
817Protein Accession#
Q9UQM7Gene Name
CAMK2D
Gene Alias
CAMKD, DKFZp686G23119, DKFZp686I2288, MGC44911
Gene Description
calcium/calmodulin-dependent protein kinase II delta
Omim ID
607708Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns
Other Designations
CaM kinase II delta subunit|CaM-kinase II delta chain|CaMK-II delta subunit|OTTHUMP00000163829|OTTHUMP00000163830|calcium/calmodulin-dependent protein kinase (CaM kinase) II delta|calcium/calmodulin-dependent protein kinase type II delta chain
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Publication Reference
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Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.
Sevilla A, Santos CR, Vega FM, Lazo PA.
The Journal of Biological Chemistry 2004 Apr; 279(26):27458.
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p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease.
Waetzig GH, Seegert D, Rosenstiel P, Nikolaus S, Schreiber S.
The Journal of Immunology 2002 May; 168(10):5342.
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Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.
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