AR polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AR.
Immunogen
A synthetic peptide corresponding to residues surrounding S650 of human AR.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to AR.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from LoVo cells, using AR polyclonal antibody (Cat # PAB18449).
Peptide "+" means "peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — AR
Entrez GeneID
367Protein Accession#
P10275Gene Name
AR
Gene Alias
AIS, DHTR, HUMARA, KD, NR3C4, SBMA, SMAX1, TFM
Gene Description
androgen receptor
Gene Ontology
HyperlinkGene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000023450|OTTHUMP00000061928|dihydrotestosterone receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM.
Journal of Proteome Research 2005 Jul; 4(4):1339.
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Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis.
Woods A, Vertommen D, Neumann D, Turk R, Bayliss J, Schlattner U, Wallimann T, Carling D, Rider MH.
The Journal of Biological Chemistry 2003 Aug; 278(31):28434.
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Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
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