CXCR2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CXCR2.
Immunogen
A synthetic peptide corresponding to human CXCR2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to CXCR2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunofluorescence (1:500-1:1000)
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using CXCR2 polyclonal antibody (Cat # PAB18401).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CXCR2
Entrez GeneID
3579Protein Accession#
P25025Gene Name
CXCR2
Gene Alias
CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB
Gene Description
chemokine (C-X-C motif) receptor 2
Omim ID
146928Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq
Other Designations
C-X-C chemokine receptor type 2|CXC-R2|CXCR-2|CXCR2 gene for IL8 receptor type B|GRO/MGSA receptor|IL-8 receptor type 2|IL-8R B|chemokine (CXC) receptor 2|high affinity interleukin-8 receptor B|interleukin 8 receptor B|interleukin 8 receptor type 2|interl
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Interactome
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Pathway
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Disease
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Publication Reference
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Single-cell RNA sequencing analysis reveals the relationship of bone marrow and osteopenia in STZ-induced type 1 diabetic mice.
Jinjie Zhong, Xingjia Mao, Heyangzi Li, Gerong Shen, Xi Cao, Ning He, Jingyu Wang, Lintao Xu, Jun Chen, Xinghui Song, Shuangshuang Liu, Xiaoming Zhang, Yueliang Shen, Lin-Lin Wang, Chuan Xiang, Ying-Ying Chen.
Journal of Advanced Research 2022 Nov; 41:145.
Application:IHC-P, Mouse, Mouse femurs.
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Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.
Kato H, Tsuchiya N, Tokunaga K.
Genes and Immunity 2000 Jun; 1(5):330.
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Single-cell RNA sequencing analysis reveals the relationship of bone marrow and osteopenia in STZ-induced type 1 diabetic mice.
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