IL10RA polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, treated with Na2VO3 (0.3 nM, 40 mins), using IL10RA polyclonal antibody (Cat # PAB18395).
Peptide "+" means "peptide blocking".
Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using IL10RA polyclonal antibody (Cat # PAB18395).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IL10RA.
Immunogen
A synthetic peptide corresponding to residues surrounding Y496 of human IL10RA.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to IL10RA.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, treated with Na2VO3 (0.3 nM, 40 mins), using IL10RA polyclonal antibody (Cat # PAB18395).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using IL10RA polyclonal antibody (Cat # PAB18395).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL10RA
Entrez GeneID
3587Protein Accession#
Q13651Gene Name
IL10RA
Gene Alias
CDW210A, HIL-10R, IL-10R1, IL10R
Gene Description
interleukin 10 receptor, alpha
Omim ID
146933Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ.
Protein Science 2004 Oct; 13(10):2819.
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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.
Josephson K, Logsdon NJ, Walter MR.
Immunity 2001 Jul; 15(1):35.
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Signal peptide prediction based on analysis of experimentally verified cleavage sites.
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