TPH1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TPH1.
Immunogen
A synthetic peptide corresponding to amino acids 25-75 of human TPH1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to TPH1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, using TPH1 polyclonal antibody (Cat # PAB18381).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using TPH1 polyclonal antibody (Cat # PAB18381).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HepG2 cells, using TPH1 polyclonal antibody (Cat # PAB18381).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — TPH1
Entrez GeneID
7166Protein Accession#
P17752Gene Name
TPH1
Gene Alias
MGC119994, TPH, TPRH
Gene Description
tryptophan hydroxylase 1
Omim ID
191060Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others
Other Designations
indoleacetic acid-5-hydroxylase|tryptophan 5-hydroxylase|tryptophan 5-monooxygenase|tryptophan hydroxylase (tryptophan 5-monooxygenase)
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Interactome
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Pathway
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Disease
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Publication Reference
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Functional domains of human tryptophan hydroxylase 2 (hTPH2).
Carkaci-Salli N, Flanagan JM, Martz MK, Salli U, Walther DJ, Bader M, Vrana KE.
The Journal of Biological Chemistry 2006 Sep; 281(38):28105.
Application:WB-Re, Recombinant protein.
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Knockout mouse points to second form of tryptophan hydroxylase.
Veenstra-VanderWeele J, Cook EH Jr.
Molecular Interventions 2003 Mar; 3(2):72.
Application:IHC, WB, Mouse, Rat, Mouse mast cells, Rat brains.
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The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
Sze JY, Zhang S, Li J, Ruvkun G.
Development 2002 Aug; 129(16):3901.
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Functional domains of human tryptophan hydroxylase 2 (hTPH2).
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