CFTR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CFTR.
Immunogen
A synthetic peptide corresponding to residues surrounding S737 of human CFTR.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CFTR.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using CFTR polyclonal antibody (Cat # PAB18325).
Peptide "+" means "peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — CFTR
Entrez GeneID
1080Protein Accession#
P13569Gene Name
CFTR
Gene Alias
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1
Gene Description
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq
Other Designations
ATP-binding cassette sub-family C, member 7|cystic fibrosis transmembrane conductance regulator
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Interactome
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Pathway
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Disease
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Publication Reference
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Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC.
Bertog M, Smith DJ, Bielfeld-Ackermann A, Bassett J, Ferguson DJ, Korbmacher C, Harris A.
American Journal of Physiology. Cell Physiology 2000 May; 278(5):C885.
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Ovine male genital duct epithelial cells differentiate in vitro and express functional CFTR and ENaC.
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