CASR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASR.
Immunogen
A synthetic peptide corresponding to residues surrounding T888 of human CASR.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CASR.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from LoVo cells, using CASR polyclonal antibody (Cat # PAB18311).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using CASR polyclonal antibody (Cat # PAB18311).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CASR
Entrez GeneID
846Protein Accession#
P41180Gene Name
CASR
Gene Alias
CAR, FHH, FIH, GPRC2A, HHC, HHC1, MGC138441, NSHPT, PCAR1
Gene Description
calcium-sensing receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq
Other Designations
extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1
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Interactome
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Disease
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Publication Reference
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Type 2 Diabetes Biomarkers and Uses Thereof.
Eustache Paramithiotis, Marc Prentki, Rèmi Rabasa-lhoret, Pascal Croteau, Joel Lanoix, Murthy S. R. Madiraju, Érik Joly
United States Patent Application Publication 2015 Nov; [Epub].
Application:IF, WB, Human, Mouse, Rat, Islets, INS832/13, MIN6 cells.
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Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin.
Huang Y, Niwa J, Sobue G, Breitwieser GE.
Journal of Biological Chemistry 2006 Apr; 281(17):11610.
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Type 2 Diabetes Biomarkers and Uses Thereof.
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