TNNI3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNNI3.
Immunogen
A synthetic peptide corresponding to residues surrounding S43 of human TNNI3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to TNNI3.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells, using TNNI3 polyclonal antibody (Cat # PAB18306).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human heart tissue using TNNI3 polyclonal antibody (Cat # PAB18306).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNNI3
Entrez GeneID
7137Protein Accession#
P19429Gene Name
TNNI3
Gene Alias
CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI
Gene Description
troponin I type 3 (cardiac)
Gene Ontology
HyperlinkGene Summary
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq
Other Designations
familial hypertrophic cardiomyopathy 7|troponin I, cardiac
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Interactome
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Pathway
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Disease
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Publication Reference
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Does coronary vasodilation after adenosine override endothelin-1-induced coronary vasoconstriction?
Loghin C, Sdringola S, Gould KL.
American Journal of Physiology. Heart and Circulatory Physiology 2007 Jan; 292(1):H496.
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Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility.
Brotto MA, Biesiadecki BJ, Brotto LS, Nosek TM, Jin JP.
American Journal of Physiology. Cell Physiology 2006 Feb; 290(2):C567.
Application:WB-Ti, Rat, Rat muscle tissues.
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Expression of slow skeletal troponin I in hearts of phospholamban knockout mice alters the relaxant effect of beta-adrenergic stimulation.
Wolska BM, Arteaga GM, Pena JR, Nowak G, Phillips RM, Sahai S, de Tombe PP, Martin AF, Kranias EG, Solaro RJ.
Circulation Research 2002 May; 90(8):882.
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Does coronary vasodilation after adenosine override endothelin-1-induced coronary vasoconstriction?
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