BLM polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BLM.
Immunogen
A synthetic peptide corresponding to human BLM.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to BLM.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lymph node tissue using BLM polyclonal antibody (Cat # PAB18272).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of A-549 cells, using BLM polyclonal antibody (Cat # PAB18272).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BLM
Entrez GeneID
641Protein Accession#
P54132Gene Name
BLM
Gene Alias
BS, MGC126616, MGC131618, MGC131620, RECQ2, RECQL2, RECQL3
Gene Description
Bloom syndrome
Gene Ontology
HyperlinkGene Summary
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. [provided by RefSeq
Other Designations
Bloom syndrome protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB.
Molecular and Cellular Biology 2004 Oct; 24(19):8437.
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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.
Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.
The Journal of Biological Chemistry 2002 Oct; 277(43):41110.
Application:ELISA, Recombinant protein.
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Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes.
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