PLD1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PLD1.
Immunogen
A synthetic peptide corresponding to human PLD1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to PLD1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using PLD1 polyclonal antibody (Cat # PAB18260).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLD1
Entrez GeneID
5337Protein Accession#
Q13393Gene Name
PLD1
Gene Alias
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Gene Description
phospholipase D1, phosphatidylcholine-specific
Omim ID
602382Gene Ontology
HyperlinkGene Summary
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM
Other Designations
choline phosphatase 1|phospholipase D1, phophatidylcholine-specific
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Interactome
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Pathway
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Disease
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Publication Reference
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Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage.
Zeniou-Meyer M, Zabari N, Ashery U, Chasserot-Golaz S, Haeberle AM, Demais V, Bailly Y, Gottfried I, Nakanishi H, Neiman AM, Du G, Frohman MA, Bader MF, Vitale N.
The Journal of Biological Chemistry 2007 Jul; 282(30):21746.
Application:WB-Tr, Bovine, Rat, Bovine adrenal chromaffin cells, PC12 cells.
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Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2.
Lehman N, Di Fulvio M, McCray N, Campos I, Tabatabaian F, Gomez-Cambronero J.
Blood 2006 Nov; 108(10):3564.
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Independent functioning of cytosolic phospholipase A2 and phospholipase D1 in Trp-Lys-Tyr-Met-Val-D-Met-induced superoxide generation in human monocytes.
Bae YS, Kim Y, Kim JH, Lee TG, Suh PG, Ryu SH.
The Journal of Immunology 2000 Apr; 164(8):4089.
Application:WB-Ce, Human, Monocytes.
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Phospholipase D1 production of phosphatidic acid at the plasma membrane promotes exocytosis of large dense-core granules at a late stage.
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