BCAR1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCAR1 polyclonal antibody (Cat # PAB18252).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCAR1.
Immunogen
A synthetic peptide corresponding to human BCAR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to BCAR1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCAR1 polyclonal antibody (Cat # PAB18252).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCAR1
Entrez GeneID
9564Protein Accession#
P56945Gene Name
BCAR1
Gene Alias
CAS, CAS1, CASS1, CRKAS, P130Cas
Gene Description
breast cancer anti-estrogen resistance 1
Omim ID
602941Gene Ontology
HyperlinkGene Summary
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM
Other Designations
Cas scaffolding protein family member 1|Crk-associated substrate p130Cas
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Interactome
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Pathway
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Disease
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Publication Reference
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p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
Cabodi S, Tinnirello A, Di Stefano P, Bisaro B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P.
Cancer Research 2006 May; 66(9):4672.
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Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry.
Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR.
The Journal of Biological Chemistry 2000 May; 275(19):14729.
Application：IP, Human, SW480 cells.
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p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
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