Western blot analysis of extracts from Jurkat cells (Lane 1 and 4), COLO 205 cells (Lane 2) and 293 cells (Lane 3), using GRIN1 polyclonal antibody (Cat # PAB18251). Peptide "+" means "peptide blocking".
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq