STK11 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STK11.
Immunogen
A synthetic peptide corresponding to human STK11.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to STK11.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STK11 polyclonal antibody (Cat # PAB18243).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of NIH/3T3 cells, using STK11 polyclonal antibody (Cat # PAB18243).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — STK11
Entrez GeneID
6794Protein Accession#
Q15831Gene Name
STK11
Gene Alias
LKB1, PJS
Gene Description
serine/threonine kinase 11
Gene Ontology
HyperlinkGene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
polarization-related protein LKB1|serine/threonine protein kinase 11
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Interactome
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Pathway
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Disease
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Publication Reference
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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC.
The EMBO Journal 2003 Jun; 22(12):3062.
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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
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