IRS1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRS1.
Immunogen
A synthetic peptide corresponding to human IRS1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to IRS1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using IRS1 polyclonal antibody (Cat # PAB18242).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRS1
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Interactome
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Pathway
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Disease
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Publication Reference
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Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
Tzatsos A, Tsichlis PN.
The Journal of Biological Chemistry 2007 Jun; 282(25):18069.
Application:WB, Human, HEK 293 cells, L6 myoblasts.
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Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM.
Molecular and Cellular Biology 2006 Dec; 26(24):9338.
Application:WB-Ti, Mouse, PyV-MT mammary tumors.
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Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
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