XIAP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of XIAP.
Immunogen
A synthetic peptide corresponding to residues surrounding S87 of human XIAP.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to XIAP.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells, using XIAP polyclonal antibody (Cat # PAB18234).
Peptide "+" means "peptide blocking".Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — XIAP
Entrez GeneID
331Protein Accession#
P98170Gene Name
XIAP
Gene Alias
API3, BIRC4, ILP1, MIHA, XLP2
Gene Description
X-linked inhibitor of apoptosis
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. [provided by RefSeq
Other Designations
OTTHUMP00000023975|OTTHUMP00000196392|apoptosis inhibitor 3|baculoviral IAP repeat-containing 4|baculoviral IAP repeat-containing protein 4
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Interactome
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Pathway
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Disease
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Publication Reference
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XIAP activity dictates Apaf-1 dependency for caspase 9 activation.
Ho AT, Li QH, Okada H, Mak TW, Zacksenhaus E.
Molecular and Cellular Biology 2007 Aug; 27(16):5673.
Application:WB-Ce, Mouse, Fibroblasts, Myoblasts.
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Hypermethylation of XIAP-associated factor 1, a putative tumor suppressor gene from the 17p13.2 locus, in human gastric adenocarcinomas.
Byun DS, Cho K, Ryu BK, Lee MG, Kang MJ, Kim HR, Chi SG.
Cancer Research 2003 Nov; 63(21):7068.
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XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.
Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM.
The Journal of Experimental Medicine 2003 Jul; 198(2):341.
Application:IHC-P, WB-Ce, Human, L1236, L591, L428, KMH2, L1309 cells, Hodgkin's lymphoma.
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XIAP activity dictates Apaf-1 dependency for caspase 9 activation.
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