BIRC5 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC5.
Immunogen
A synthetic peptide corresponding to human BIRC5.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to BIRC5.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BIRC5 polyclonal antibody (Cat # PAB18223).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BIRC5
Entrez GeneID
332Protein Accession#
O15392Gene Name
BIRC5
Gene Alias
API4, EPR-1
Gene Description
baculoviral IAP repeat-containing 5
Omim ID
603352Gene Ontology
HyperlinkGene Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq
Other Designations
apoptosis inhibitor 4|baculoviral IAP repeat-containing protein 5|survivin variant 3 alpha
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis.
Marconi A, Dallaglio K, Lotti R, Vaschieri C, Truzzi F, Fantini F, Pincelli C.
Stem Cells 2007 Jan; 25(1):149.
Application:IF, IHC-P, WB, Human, Human keratinocyte, Skin.
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Survivin-directed RNA interference cocktail is a potent suppressor of tumour growth in vivo.
Caldas H, Holloway MP, Hall BM, Qualman SJ, Altura RA.
Journal of Medical Genetics 2006 Feb; 43(2):119.
Application:IHC-P, WB-Tr, Human, Human rhabdomyosarcoma, RMS cells.
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Survivin enhances Fas ligand expression via up-regulation of specificity protein 1-mediated gene transcription in colon cancer cells.
Asanuma K, Tsuji N, Endoh T, Yagihashi A, Watanabe N.
Journal of Immunology 2004 Mar; 172(6):3922.
Application:IHC, WB-Tr, Human, Human colon cancers, LS180, SW480 cells.
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Survivin identifies keratinocyte stem cells and is downregulated by anti-beta1 integrin during anoikis.
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