MED1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MED1.
Immunogen
A synthetic peptide corresponding to human MED1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to MED1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using MED1 polyclonal antibody (Cat # PAB18212).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — MED1
Entrez GeneID
5469Protein Accession#
Q15648Gene Name
MED1
Gene Alias
CRSP1, CRSP200, DRIP205, DRIP230, MGC71488, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Gene Description
mediator complex subunit 1
Omim ID
604311Gene Ontology
HyperlinkGene Summary
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq
Other Designations
PPAR binding protein|PPARG binding protein|thyroid hormone receptor-associated protein complex component TRAP220|thyroid receptor interacting protein 2|vitamin D receptor-interacting protein 230 kD|vitamin D receptor-interacting protein complex component
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Interactome
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Disease
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Publication Reference
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Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.
Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W.
International Journal of Cell Biology 2001 Aug; 154(4):799.
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Cloning and function of rabbit peroxisome proliferator-activated receptor delta/beta in mature osteoclasts.
Mano H, Kimura C, Fujisawa Y, Kameda T, Watanabe-Mano M, Kaneko H, Kaneda T, Hakeda Y, Kumegawa M.
The Journal of Biological Chemistry 2000 Mar; 275(11):8126.
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Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.
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