PLN polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PLN.
Immunogen
A synthetic peptide corresponding to human PLN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to PLN.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunofluorescence (1:500-1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using PLN polyclonal antibody (Cat # PAB18209).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLN
Entrez GeneID
5350Protein Accession#
P26678Gene Name
PLN
Gene Alias
CMD1P, PLB
Gene Description
phospholamban
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq
Other Designations
OTTHUMP00000017092|cardiac phospholamban
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Interactome
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Pathway
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Disease
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Publication Reference
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The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.
Pessach I, Shmelzer Z, Leto TL, Dinauer MC, Levy R.
Journal of Leukocyte Biology 2006 Sep; 80(3):630.
Application:WB-Ce, Human, X-CGD PLB 91CT cells.
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Class IA phosphatidylinositide 3-kinases, rather than p110 gamma, regulate formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis and superoxide production in differentiated neutrophil-like PLB-985 cells.
Boulven I, Levasseur S, Marois S, Pare G, Rollet-Labelle E, Naccache PH.
Journal of Immunology 2006 Jun; 176(12):7621.
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PU.1 is dominant and HAF-1 supplementary for activation of the gp91(phox) promoter in human monocytic PLB-985 cells.
Islam MR, Fan C, Fujii Y, Hao LJ, Suzuki S, Kumatori A, Yang D, Rusvai E, Suzuki N, Kikuchi H, Nakamura M.
Journal of Biochemistry 2002 Apr; 131(4):533.
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The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation.
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