FOXO1/FOXO3/FOXO4 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FOXO1/FOXO3/FOXO4.
Immunogen
A synthetic peptide corresponding to human FOXO1/FOXO3/FOXO4.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to FOXO1/FOXO3/FOXO4.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using FOXO1/FOXO3/FOXO4 polyclonal antibody (Cat # PAB18176).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
-
Gene Info — FOXO1
Entrez GeneID
2308Gene Name
FOXO1
Gene Alias
FKH1, FKHR, FOXO1A
Gene Description
forkhead box O1
Gene Ontology
HyperlinkGene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018301|forkhead box O1A (rhabdomyosarcoma)|forkhead homolog in rhabdomyosarcoma|forkhead, Drosophila, homolog of, in rhabdomyosarcoma
-
Gene Info — FOXO3
Entrez GeneID
2309Gene Name
FOXO3
Gene Alias
AF6q21, DKFZp781A0677, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, MGC12739, MGC31925
Gene Description
forkhead box O3
Omim ID
602681Gene Ontology
HyperlinkGene Summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq
Other Designations
OTTHUMP00000016944|forkhead box O3A|forkhead homolog (rhabdomyosarcoma) like 1|forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
-
Gene Info — FOXO4
Entrez GeneID
4303Gene Name
FOXO4
Gene Alias
AFX, AFX1, MGC120490, MLLT7
Gene Description
forkhead box O4
Omim ID
300033Gene Ontology
HyperlinkGene Summary
7|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog
Other Designations
OTTHUMP00000023496|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 7|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Foxo3 is required for the regulation of oxidative stress in erythropoiesis.
Marinkovic D, Zhang X, Yalcin S, Luciano JP, Brugnara C, Huber T, Ghaffari S.
The Journal of Clinical Investigation 2007 Aug; 117(8):2133.
Application:IF, WB-Tr, Human, Mouse, HEK 293T cells, Mouse fetal liver erythroid subpopulations.
-
Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.
Kodama S, Koike C, Negishi M, Yamamoto Y.
Molecular and Cellular Biochemistry 2004 Sep; 24(18):7931.
Application:Func, Recombinant protein.
-
Foxo3 is required for the regulation of oxidative stress in erythropoiesis.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com