PTK2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PTK2.
Immunogen
A synthetic peptide corresponding to human PTK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to PTK2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HeLa cells, treated with EGF (200 ng/mL, 30 mins), using PTK2 polyclonal antibody (Cat # PAB18173).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using PTK2 polyclonal antibody (Cat # PAB18173).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — PTK2
Entrez GeneID
5747Protein Accession#
Q05397Gene Name
PTK2
Gene Alias
FADK, FAK, FAK1, pp125FAK
Gene Description
PTK2 protein tyrosine kinase 2
Omim ID
600758Gene Ontology
HyperlinkGene Summary
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. [provided by RefSeq
Other Designations
focal adhesion kinase 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake.
Bruce-Staskal PJ, Weidow CL, Gibson JJ, Bouton AH.
Journal of Cell Science 2002 Jul; 115(Pt 13):2689.
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PTEN-independent induction of caspase-mediated cell death and reduced invasion by the focal adhesion targeting domain (FAT) in human astrocytic brain tumors which highly express focal adhesion kinase (FAK).
Jones G, Machado J Jr, Tolnay M, Merlo A.
Cancer Research 2001 Aug; 61(15):5688.
Application:IHC, WB, Human, Human glial tumors, LN-229, LN-401 cells.
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Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake.
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