STAT5B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STAT5B.
Immunogen
A synthetic peptide corresponding to human STAT5B.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to STAT5B.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:40000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Raw 264.7 cells, treated with EGF (200 ng/mL 30 min), using STAT5B polyclonal antibody (Cat # PAB18138).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using STAT5B polyclonal antibody (Cat # PAB18138).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — STAT5B
Entrez GeneID
6777Protein Accession#
P51692Gene Name
STAT5B
Gene Alias
STAT5
Gene Description
signal transducer and activator of transcription 5B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq
Other Designations
transcription factor STAT5B
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Interactome
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Pathway
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Disease
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Publication Reference
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STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.
Benitah SA, Valeron PF, Rui H, Lacal JC.
Molecular and Cellular Biology 2003 Jan; 14(1):40.
Application:WB-Tr, Dog, MDCK cells.
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Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
Nagy ZS, Wang Y, Erwin-Cohen RA, Aradi J, Monia B, Wang LH, Stepkowski SM, Rui H, Kirken RA.
Journal of Leukocyte Biology 2002 Oct; 72(4):819.
Application:IP, WB-Ce, Human, T cells.
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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
Stepkowski SM, Erwin-Cohen RA, Behbod F, Wang ME, Qu X, Tejpal N, Nagy ZS, Kahan BD, Kirken RA.
Blood 2002 Jan; 99(2):680.
Application:IP, WB, Human, Rat, T cells.
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STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA.
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