PLCG2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PLCG2.
Immunogen
A synthetic peptide corresponding to human PLCG2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to PLCG2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from COLO 205 cells, using PLCG2 polyclonal antibody (Cat # PAB18130).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLCG2 polyclonal antibody (Cat # PAB18130).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLCG2
Entrez GeneID
5336Protein Accession#
P16885Gene Name
PLCG2
Gene Alias
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Gene Description
phospholipase C, gamma 2 (phosphatidylinositol-specific)
Omim ID
600220Gene Ontology
HyperlinkGene Summary
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM
Other Designations
phospholipase C gamma 2|phospholipase C, gamma 2|phospholipase C, gamma 2 (phosphatidylyinositol-specific)
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Interactome
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Pathway
- B cell receptor signaling pathway
- Calcium signaling pathway
- Epithelial cell signaling in Helicobacter pylori infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Glioma
- Inositol phosphate metabolism
- Leukocyte transendothelial migration
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Disease
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Publication Reference
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PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.
Mao D, Epple H, Uthgenannt B, Novack DV, Faccio R.
The Journal of Clinical Investigation 2006 Nov; 116(11):2869.
Application:WB, Mouse, Mouse macrophages.
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Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells.
Caraux A, Kim N, Bell SE, Zompi S, Ranson T, Lesjean-Pottier S, Garcia-Ojeda ME, Turner M, Colucci F.
Blood 2006 Feb; 107(3):994.
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Activation of phospholipase Cgamma2 by tyrosine phosphorylation.
Ozdener F, Dangelmaier C, Ashby B, Kunapuli SP, Daniel JL.
Molecular Pharmacology 2002 Sep; 62(3):672.
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PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2.
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