BCAR1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCAR1.
Immunogen
A synthetic peptide corresponding to human BCAR1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to BCAR1.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using BCAR1 polyclonal antibody (Cat # PAB18127).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCAR1 polyclonal antibody (Cat # PAB18127).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCAR1
Entrez GeneID
9564Protein Accession#
P56945Gene Name
BCAR1
Gene Alias
CAS, CAS1, CASS1, CRKAS, P130Cas
Gene Description
breast cancer anti-estrogen resistance 1
Omim ID
602941Gene Ontology
HyperlinkGene Summary
BCAR1, or CAS, is an Src (MIM 190090) family kinase substrate involved in various cellular events, including migration, survival, transformation, and invasion (Sawada et al., 2006 [PubMed 17129785]).[supplied by OMIM
Other Designations
Cas scaffolding protein family member 1|Crk-associated substrate p130Cas
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Interactome
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Pathway
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Disease
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Publication Reference
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Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
Modzelewska K, Newman LP, Desai R, Keely PJ.
Journal of Biological Chemistry 2006 Dec; 281(49):37527.
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A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction.
Ogden K, Thompson JM, Hickner Z, Huang T, Tang DD, Watts SW.
American Journal of Physiology. Heart and Circulatory Physiology 2006 Dec; 291(6):H2857.
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Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.
Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R.
Cancer Research 2005 Oct; 65(20):9185.
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Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.
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