LYN polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells treated with H2O2 (100 uM, 30 mins), using LYN polyclonal antibody (Cat # PAB18126).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using LYN polyclonal antibody (Cat # PAB18126).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LYN.
Immunogen
A synthetic peptide corresponding to human LYN.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to LYN.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:300-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells treated with H2O2 (100 uM, 30 mins), using LYN polyclonal antibody (Cat # PAB18126).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using LYN polyclonal antibody (Cat # PAB18126).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CD180
Entrez GeneID
4064Protein Accession#
P07948Gene Name
CD180
Gene Alias
LY64, Ly78, MGC126233, MGC126234, RP105
Gene Description
CD180 molecule
Omim ID
602226Gene Ontology
HyperlinkGene Summary
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq
Other Designations
CD180 antigen|lymphocyte antigen-64, radioprotective, 105kDa
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Interactome
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Disease
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Publication Reference
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Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR-383/RP105/AKT signalling pathway.
Xin Guo, Shan Hu, Ji-Jun Liu, Ling Huang, Peng Zhong, Zhi-Xing Fan, Ping Ye, Man-Hua Chen.
Journal of Cellular and Molecular Medicine 2021 Jan; 25(1):244.
Application：IF, WB-Ti, WB-Tr, Rat, Rat cardiomyocytes, Rat heart tissues.
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Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T.
Journal of Immunology 2005 Nov; 175(10):6885.
Application：IP-WB, WB-Ce, Mouse, BMMCs.
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Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.
Contri A, Brunati AM, Trentin L, Cabrelle A, Miorin M, Cesaro L, Pinna LA, Zambello R, Semenzato G, Donella-Deana A.
The Journal of Clinical Investigation 2005 Feb; 115(2):369.
Application：IF, IP, WB, Human, Leukemic B cells, Normal B lymphocytes from CLL patients.
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A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma.
Li FJ, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano MM.
Blood 2005 Apr; 105(8).
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Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR-383/RP105/AKT signalling pathway.
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