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Last updated: 2017/1/15
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APAF1 polyclonal antibody

  • Catalog # : PAB18086
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of APAF1.
  • Immunogen:
  • A synthetic peptide corresponding to human APAF1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody is specific to APAF1.
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:500~1:1000)
    Immunohistochemistry (1:50~1:100)
    ELISA(1:10000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extracts from COLO 205, using APAF1 polyclonal antibody (Cat # PAB18086).
    Peptide "+" means "with peptide blocking".
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using APAF1 polyclonal antibody (Cat # PAB18086).
    Peptide "+" means "with peptide blocking".
  • Immunohistochemistry
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunohistochemistry
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 317
  • Gene Name:
  • APAF1
  • Gene Alias:
  • CED4,DKFZp781B1145
  • Gene Description:
  • apoptotic peptidase activating factor 1
  • Gene Summary:
  • This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • apoptotic protease activating factor 1
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