ADRB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRB2.
Immunogen
A synthetic peptide corresponding to human ADRB2.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to ADRB2.
Form
Liquid
Recommend Usage
Western Blot (1:500~1:1000)
Immunofluorescence (1:500~1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, using ADRB2 polyclonal antibody (Cat # PAB18065).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of COS-7 cells, using ADRB2 polyclonal antibody (Cat # PAB18065).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ADRB2
Entrez GeneID
154Protein Accession#
P07550Gene Name
ADRB2
Gene Alias
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
Gene Description
adrenergic, beta-2-, receptor, surface
Gene Ontology
HyperlinkGene Summary
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq
Other Designations
beta-2 adrenergic receptor|beta-2 adrenoceptor|catecholamine receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Primary structure of the human beta-adrenergic receptor gene.
Schofield PR, Rhee LM, Peralta EG.
Nucleic Acids Research 1987 Apr; 15(8):3636.
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Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.
Chung FZ, Lentes KU, Gocayne J, Fitzgerald M, Robinson D, Kerlavage AR, Fraser CM, Venter JC.
FEBS Letters 1987 Jan; 211(2):200.
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cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ.
PNAS 1987 Jan; 84(1):46.
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Primary structure of the human beta-adrenergic receptor gene.
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