ACVRL1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACVRL1.
Immunogen
A synthetic peptide corresponding to human ACVRL1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ACVRL1.
Form
Liquid
Recommend Usage
Western Blot (1:500~1:1000)
Immunohistochemistry (1:50~1:100)
Immunofluorescence (1:500~1:1000)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells, using ACVRL1 polyclonal antibody (Cat # PAB18054).
Peptide "+" means "with peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ACVRL1 polyclonal antibody (Cat # PAB18054).
Peptide "+" means "with peptide blocking".Immunohistochemistry
Immunofluorescence
Immunofluorescence analysis of HeLa cells, using ACVRL1 polyclonal antibody (Cat # PAB18054).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACVRL1
Entrez GeneID
94Protein Accession#
P37023Gene Name
ACVRL1
Gene Alias
ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
Gene Description
activin A receptor type II-like 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
Other Designations
TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 1|serine/threonine-protein kinase receptor R3
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Interactome
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Pathway
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Disease
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Publication Reference
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The Expression of Activin Receptor-Like Kinase 1 among Patients with Head and Neck Cancer.
Chien CY, Chuang HC, Chen CH, Fang FM, Chen WC, Huang CC, Huang HY.
Otolaryngology-Head and Neck Surgery 2013 Jun; 148(6):965.
Application:IHC, Human, Human squamous cell carcinoma.
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The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2.
Berg JN, Gallione CJ, Stenzel TT, Johnson DW, Allen WP, Schwartz CE, Jackson CE, Porteous ME, Marchuk DA.
American Journal of Human Genetics 1997 Jul; 61(1):60.
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Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Attisano L, Carcamo J, Ventura F, Weis FM, Massague J, Wrana JL.
Cell 1993 Nov; 75(4):671.
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Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.
ten Dijke P, Ichijo H, Franzen P, Schulz P, Saras J, Toyoshima H, Heldin CH, Miyazono K.
Oncogene 1993 Aug; 8(10).
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The Expression of Activin Receptor-Like Kinase 1 among Patients with Head and Neck Cancer.
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