ACTL6A polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells (Lane 1) and COLO 205 cells (Lane 2 and lane 3), using ACTL6A polyclonal antibody (Cat # PAB18052).
Peptide "+" means "with peptide blocking".
Immunofluorescence
Immunofluorescence analysis of HUVEC cells, using ACTL6A polyclonal antibody (Cat # PAB18052).
Peptide "+" means "with peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACTL6A.
Immunogen
A synthetic peptide corresponding to human ACTL6A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to ACTL6A.
Form
Liquid
Recommend Usage
Western Blot (1:500~1:1000)
Immunofluorescence (1:500~1:1000)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Jurkat cells (Lane 1) and COLO 205 cells (Lane 2 and lane 3), using ACTL6A polyclonal antibody (Cat # PAB18052).
Peptide "+" means "with peptide blocking".Immunofluorescence
Immunofluorescence analysis of HUVEC cells, using ACTL6A polyclonal antibody (Cat # PAB18052).
Peptide "+" means "with peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACTL6A
Entrez GeneID
86Protein Accession#
O96019Gene Name
ACTL6A
Gene Alias
ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K, MGC5382
Gene Description
actin-like 6A
Omim ID
604958Gene Ontology
HyperlinkGene Summary
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq
Other Designations
BAF complex 53 kDa subunit|BAF53|BRG1-associated factor|INO80 complex subunit K|actin-related protein 4|hArpN beta
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Interactome
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Publication Reference
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Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A.
Genome Research 2001 Mar; 11(3):422.
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Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues.
Harata M, Mochizuki R, Mizuno S.
Bioscience, Biotechnology, and Biochemistry 1999 May; 63(5):917.
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Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.
Zhao K, Wang W, Rando OJ, Xue Y, Swiderek K, Kuo A, Crabtree GR.
Cell 1998 Nov; 95(5):625.
Application：IF, WB-Ce, Human, Jurkat, SW-13 cells.
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Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
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